Street-smart Nathan Drake is recruited by seasoned treasure hunter Victor "Sully" Sullivan to recover a fortune amassed by Ferdinand Magellan and lost 500 years ago by the House of Moncada. What starts as a heist job for the duo becomes a globe-trotting, white-knuckle race to reach the prize before the ruthless Santiago Moncada, who believes he and his family are the rightful heirs. If Nate and Sully can decipher the clues and solve one of the world's oldest mysteries, they stand to find $5 billion in treasure and perhaps even Nate's long-lost brother ... but only if they can learn to work together.