Biologist and wildlife photographer Clayton Porter witnesses what appears to be a routine drug-smuggling flight across the Arizona-Mexico border. Instead, he uncovers a sophisticated operation involving a secret lodge high in the Sierra Madre, canned hunts for endangered jaguars, a ring of opioid-dealing doctors in the U.S., and a string of cartel victims partially consumed by a large predator. After he unwittingly throws a wrench into the works, Porter becomes a target of revenge, and resorts to skills from his military service to save himself and those close to him.